Cathepsin D gene Expression in Stomach: Its Association with Age, Sex, and Menopausal status
نویسندگان
چکیده مقاله:
Background & Objectives :Gastric cancer is 2-4 folds higher in men than women. Sex hormones are one of the leading causes of sexual dimorphism in incidence of gastric cancer. The aim of this study is to compare Cathepsin D and Caspase-7 gene expressions in the gastric tissue of normal men and women. Materials & Methods :In this cross-sectional study, gastric antrum tissue samples were collected from 21 healthy females and 21 males in the three age groups including 35, 35-50, and over 50 years. Following RNA extraction and cDNA synthesis, the expressions of genes were compared between men and women via semi-quantitative Reverse Transcription-PCR method. The obtained data were analyzed, using the statistical T-Test and ANOVA. Results: Statical analyses confirmed that the expression of Cathepsin D gene was significantly higher in men under 35 than those in the range of 35-50 years (p=0.04). In addition, the expression of Cathepsin D gene was significantly 10 folds in pre-menopause than post-menopause women and men (post-menopause women and men as one group) (p=0.008). Furthermore, the expression of Cathepsin D gene between men and women was significant at borderline (p=0.056). Conclusion: The findings of the present research indicate that the expression of Cathepsin D is higher in pre-menopause than post-menopause women and men, and is greater in men under 35 than those in the range of 35-50 years.
منابع مشابه
the past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولVitamin D Status and Its Association with Attention Deficit Hyperactivity Disorder (ADHD) in Children
متن کامل
PTEN Gene Expression and Its Association with rs10490920 SNP in Breast Cancer
Introduction: The PTEN gene, also known as MMAC1 or TEP1, is a tumor suppressor gene. One of the important polymorphisms of this gene is the rs10490920 SNP. The purpose of this study was to determine the PTEN gene expression and its relation to changes in rs10490920 polymorphism in breast cancer. Methods: In this study, 40 breast cancer patients and 10 healthy controls were considered. The expr...
متن کاملInvestigating the methylation status of DACT2 gene and its association with MTHFR C677T polymorphism in patients with colorectal cancer
Colorectal cancer (CRC) is one of the common causes of cancer death in Iranian population. Both genetic and epigenetic changes have been implicated in CRC pathogenesis. DACT2 gene as one of the WNT signaling pathway inhibitor was shown to display tumor suppressor activity in many cancers. The aim of present study was to investigate the methylation status of DACT2 gene and its ...
متن کاملInsulin Resistance and its Relevance with Age, Sex, Season and Obesity in Darehshori Horse Breed
BACKGROUND: Equine metabolic syndrome is an endocrinopathy that affects different breeds of horses and ponies. This metabolic disorder is a multifactorial syndrome and it is primarily linked to obesity, dyslipidemia and insulin resistance. OBJECTIVES: The present study was performed to evaluate insulin resistance in Darehshori horses with regards to age, sex, season and obesity. METHODS: Twelve...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 5 شماره 4
صفحات 508- 515
تاریخ انتشار 2016-03
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
کلمات کلیدی برای این مقاله ارائه نشده است
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023